St. Louis is one of the largest cities in the Midwest, and has one of the largest metropolitan areas, in the Midwest, United States. It is located near the confluence of the Mississippi and the Missouri Rivers. In 2020, the city proper had a population of 301,578, its bi-state metropolitan area, which extends into Illinois, had an estimated population of over 2.8 million, making it the largest metropolitan area in Missouri and the second-largest in Illinois.
